Graphene nanomaterials are outstanding carrier materials for drug delivery applications. The specific structure-associated properties enable high loading efficiency, functionalization capacity for targeting, imaging, sensing, stimuli responsive release, etc.
What is graphene used for in medicine?
Graphene oxide (GO), an oxidized derivative of graphene, is currently used in biotechnology and medicine for cancer treatment, drug delivery, and cellular imaging. Also, GO is characterized by various physicochemical properties, including nanoscale size, high surface area, and electrical charge.
Why is graphene oxide used in medicine?
Graphene and graphene oxide have been widely investigated for biomedical applications due to their exceptional qualities: twodimensional planar structure, wide surface area, chemical and mechanical constancy, sublime conductivity and excellent biocompatibility.
Which drugs use graphene oxide?
Table 1
| GO composite | Drug/gene | References |
|---|---|---|
| CPMAA2-GON-PEG | DOX | 103 |
| PAA-GO | BCNU | 104 |
| NGO-SS-PE | DOX | 105 |
| Graphene/Fe3O4 | DOX | 106–108 |
Why is graphene useful?
Graphene has emerged as one of the most promising nanomaterials because of its unique combination of exceptional properties: it is not only the thinnest but also one of the strongest materials; it conducts heat better than all other materials; it is an excellent conductor of electricity; it is optically transparent,
What are the side effects of graphene oxide?
Concentration. Numerous results have shown that graphene materials cause dose-dependent toxicity in animals and cells, such as liver and kidney injury, lung granuloma formation, decreased cell viability and cell apoptosis [130–134].
What is the use of graphene in nanotechnology?
There are four areas that graphene nanotechnology can find application in renewable energy. These areas are (1) hydrogen fuel cells, (2) solar (photovoltaic) cells, (3) battery-powered vehicles, and (4) energy storage devices and other applications [16].
Is graphene hydroxide used in medicine?
The biomedical applications of graphene and its composite include its use in gene and small molecular drug delivery. It is further used for biofunctionalization of protein, in anticancer therapy, as an antimicrobial agent for bone and teeth implantation.
Graphene materials show excellent inhibitory antiviral effects against enveloped and non-enveloped viruses, including RNA and DNA viruses. These performances which are attributed to the physicochemical properties exhibited on the surfaces of these materials, can be used to control the COVID-19 pandemic.
How do you detect graphene oxide?
Just one drop of blood for a diagnosis
A single drop of blood or saliva is all it takes to perform an accurate analysis. Just a few minutes after the drop is applied to the sensor’s surface, electrical signals convey the test result to the family doctor’s office.
What does graphene do to the blood?
Even though graphene oxide is made with the same atoms as our organs, tissues and cells, its bi-dimensional nature causes unique interactions with blood proteins and biological membranes and can lead to severe effects like thrombogenicity and immune cell activation.
Is graphene toxic?
Rationales provided for this are that graphene is not toxic, that exposure is low, that small amounts are expected to be produced and used, that graphene can be made safe, that graphene is similar to harmless materials (e.g., being “just carbon”), and that graphene is different from hazardous materials such as carbon
How does the graphene works?
Graphene is a single layer of carbon atoms, arranged hexagonally, in a chicken-wire structure.Without these interactions, as in a sheet of graphene, electrons behave as though they are massless particles, moving freely through empty space, at close to the speed of light.
What is meant by graphene oxide?
Graphene oxide (GO) is a unique material that can be viewed as a single monomolecular layer of graphite with various oxygen-containing functionalities such as epoxide, carbonyl, carboxyl, and hydroxyl groups.
Does graphene oxide have magnetic properties?
The magnetic properties of OD and GO were studied. The results showed that OD has a low magnetization of 0.16 emu/g, and the magnetization of GO can be increased from 0.38 to 0.42 emu/g by discarding low-magnetization OD. Thus, this study provided a reliable method to increase the magnetization of GO.
What is the strength of graphene?
130,000,000,000 Pascals
Mechanical Strength
Due to the strength of its 0.142 Nm-long carbon bonds, graphene is the strongest material ever discovered, with an ultimate tensile strength of 130,000,000,000 Pascals (or 130 gigapascals), compared to 400,000,000 for A36 structural steel, or 375,700,000 for Aramid (Kevlar).
What’s the difference between graphene oxide and graphene hydroxide?
The difference between GO and rGO is the presence of more hydroxyl, carboxyl, and ether functional groups on the surface of GO sheets, which can be effective in interacting with other compounds or dispersing in water.
How is graphene oxide removed from blood?
Treating GO with hydrazine hydrate and maintaining the solution at 100 for 24 hours. Exposing GO to hydrogen plasma for a few seconds. Exposing GO to another form of strong pulse light, such as those produced by xenon flashtubes.
Can graphene cross blood brain barrier?
Recently, graphene quantum dots (GQDs) have earned attention in biomedicine and nanomedicine, thanks to their higher biocompatibility and low cytotoxicity compared to other QDs. GQDs share the optical properties of QD and have proven ability to cross the blood-brain barrier (BBB).
Can graphene conduct electricity?
Graphene has high electrical conductivity and excellent transmittance at terahertz frequencies, so Wu, M.S. et al.
How long does graphene oxide stay in the body?
“A significantly larger fraction of the thicker GO sheet (47.5% of the injected dose) remain in the body 24 hours after administration, mainly in the spleen and liver,” say Jasim and Kostarelos. “By contrast, the thinner GO sheets (76.9%) were excreted in the urine.”
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