Most depot medications belong to the older group of antipsychotics (‘first generation’ or ‘typical’ antipsychotics). These are Modecate, Depixol, Haldol, Piportil and Clopixol.
What antipsychotics can be given as depot?
Antipsychotic depot injections
| Antipsychotic depot injections | Preparations |
|---|---|
| Aripiprazole | 400mg injection |
| Flupentixol decanoate | 20mg/ml, 40mg/2ml, 50mg/0.5ml, 100mg/1ml, 200mg/ml injection |
| Haloperidol decanoate | 50mg/ml, 100mg/ml injection |
| Paliperidone palmitate 1-monthly(Xeplion®) | 50mg, 75mg, 100mg, 150mg pre-filled syringes |
What antipsychotics come in injection form?
Second-generation atypical antipsychotics available for long-acting injection include:
- risperidone (Perseris Kit, Indivior Inc.; Risperdal Consta, Janssen),
- olanzapine pamoate (Zyprexa Relprevv, Eli Lilly),
- paliperidone palmitate in two formulations (Invega Sustenna, Janssen; Invega Trinza, Janssen); and.
Are there injectable antipsychotics?
Long-acting injectable (LAI) antipsychotics are a pharmacologic strategy for treating patients with schizophrenia who relapse due to nonadherence to antipsychotic medication.
What are depot neuroleptics?
A depot injection is a slow-release form of medication. The injection uses a liquid that releases the medication slowly, so it lasts a lot longer. Depot injections can be used for various types of drug, including some antipsychotics.
Why are depot antipsychotics used?
Long-acting depot antipsychotic medications were developed in the 1960s to promote adherence in people with recurrent psychotic disorders, including schizophrenia.
What is the safest antipsychotic drug?
Clozapine and olanzapine have the safest therapeutic effect, while the side effect of neutropenia must be controlled by 3 weekly blood controls. If schizophrenia has remitted and if patients show a good compliance, the adverse effects can be controlled.
What is the newest antipsychotic drug?
Paliperidone, iloperidone, asenapine, and lurasidone are the newest oral atypical antipsychotic medications to be introduced since the approval of aripiprazole in 2002.
Table 1.
| Lurasidone (Latuda) | |
| FDA Indication | Schizophrenia |
| Starting Dose | 40 mg once daily |
| Effective Dose | 80 mg once daily |
What is the fastest acting antipsychotic?
Intramuscular olanzapine has shown faster onset of action, greater efficacy and fewer adverse effects than haloperidol or lorazepam in the treatment of acute agitation associated with schizophrenia, schizoaffective disorder, bipolar mania and dementia.
What is the advantage of an antipsychotic depot injection?
The main advantage of depot antipsychotic medication is that it overcomes the problem of covert noncompliance. Patients receiving depot treatment who refuse their injection or fail to receive it for any other reason can be immediately identified and appropriate action taken.
Does Seroquel come in shot form?
Most of the second-generation antipsychotics — such as Clozaril, Risperdal, Zyprexa, Seroquel, Geodon, and Abilify — come only in pill form. The only second-generation injectable drug for schizophrenia, Risperdal Consta, has to be given every two weeks.
What is the difference between Abilify and Abilify Maintena?
They both contain the active ingredient aripiprazole, an atypical antipsychotic, and are approved for the treatment of schizophrenia and bipolar disorder. Abilify is approved for other uses, too. Abilify comes as an oral medication taken daily, while Abilify Maintena is a long-acting injection given every 4 weeks.
Is latuda injectable?
Subjects who tolerate dosing with oral lurasidone 80 mg will receive a single lurasidone injectable suspension or placebo injection dose on Day 1. Lurasidone 80 mg will be provided as the commercially available oral tablet formulation (Latuda®). Placebo for lurasidone injectable suspension will be provided.
Can clozapine be given as a depot?
These medications are administered at intervals ranging from weekly or two-weekly to four- weekly or monthly. Some are administered in the community via “depot clinics”, others via home visits. Review of community team priority groups should include those on depots.
What does depot mean in medicine?
A depot injection is a term for an injection formulation of a medication which releases slowly over time to permit less frequent administration of a medication.
How many atypical antipsychotics are there?
There are 6 atypical antipsychotics commercially available in the United States: clozapine, risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole.
What is the difference between clopixol and Depixol?
For example, Clopixol may be more suitable if you are highly agitated, while Depixol may be more suitable if you have a low mood associated with your illness. There are also differences in the side-effects they may cause, and this will influence your choice of depot.
How long do depot injections last?
The contraceptive injection (Depo-Provera, Sayana Press or Noristerat) releases the hormone progestogen into your bloodstream to prevent pregnancy. Depo-Provera is most commonly given in the UK and lasts for 13 weeks.
Are depot injections painful?
Conclusion: Depot injections are painful. The pain they inflict has a typical course, and medication type is among the factors that influence this pain. This pain might have an effect on patients’ attitude toward depot injections and thus is of importance in the management of patients suffering from schizophrenia.
Which antipsychotic is best for anxiety?
Atypical antipsychotics such as quetiapine, aripiprazole, olanzapine, and risperidone have been shown to be helpful in addressing a range of anxiety and depressive symptoms in individuals with schizophrenia and schizoaffective disorders, and have since been used in the treatment of a range of mood and anxiety disorders
What antipsychotics have the least side effects?
Aripiprazole is similar in effectiveness to risperidone and somewhat better than ziprasidone. Aripiprazole had less side- effects than olanzapine and risperidone (such as weight gain, sleepiness, heart problems, shaking and increased cholesterol levels).
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