Lennox-Gastaut syndrome (LGS) is a type of epilepsy. Patients with LGS experience many different types of seizures including: Tonic – stiffening of the body. Atonic – temporary loss of muscle tone and consciousness, causing the patient to fall.
What causes LGS?
Examples of conditions that can cause Lennox-Gastaut syndrome include abnormal development of the brain cortex (cortical dysplasia), congenital infections, stroke, trauma, reduced oxygen supply that occurs before birth (perinatal hypoxia), infections of the central nervous system such as encephalitis or meningitis and
Can kids outgrow LGS?
A very small number of children will outgrow their seizures by their teenage years. However, the remaining children will continue to have seizures, often on a daily basis, into adult life.
Can LGS be cured?
There is no cure for LGS, although there is a lot of research to find treatments that work better. Each child with LGS has different needs. Most continue to have seizures and intellectual disabilities after they grow up.
How bad is Lennox-Gastaut Syndrome?
Lennox-Gastaut syndrome (LGS) is a severe form of childhood epilepsy with multiple types of seizures. In 1 out of 4 people, no cause can be found. About 2 to 5% of children with epilepsy have LGS. Usually, LGS persists through childhood and adolescence to adult years.
Can Lennox-Gastaut syndrome cause death?
People with Lennox-Gastaut syndrome have a higher risk of death than their peers of the same age. Although the increased risk is not fully understood, it is partly due to poorly controlled seizures and injuries from falls.
What is the life expectancy of LGS?
The characteristic diffuse slow spike wave pattern of LGS gradually disappears with age and is replaced by focal epileptic discharges, especially multiple independent spikes. Mortality rate is reported at 3% (mean follow-up period of 8.5 y) to 7% (mean follow-up period of 9.7 y). Death often is related to accidents.
Is LGS a focal epilepsy?
Focal or generalized myoclonic (formerly myoclonic)2
In people with LGS, these seizures often occur in the neck, upper arms, and shoulders.
Can Lennox-Gastaut syndrome be cured?
There is no cure for the disorder. Complete recovery, including freedom from seizures and normal development, is very rare. The prognosis for individuals with Lennox-Gastaut syndrome varies. There is no cure for the disorder.
Is Lennox-Gastaut syndrome progressive?
Lennox-Gastaut syndrome is a progressive epilepsy syndrome that causes tonic and atypical absence seizures and intellectual disability. It is difficult to treat, although some newer treatments are being investigated.
How long can you live with Lennox-Gastaut?
We investigated the long-term prognosis of Lennox-Gastaut syndrome (LGS) in 72 patients followed up for > 10 years. Long-term seizure and intellectual outcomes were poor, as previously reported. The diagnosis of LGS was first made in the age range from 2 to 15 years with peak occurrence at 5 years.
Can adults have Lennox-Gastaut Syndrome?
Lennox-Gastaut syndrome (LGS) is a severe epileptic encephalopathy with childhood onset that usually continues through adolescence and into adulthood. In the long term, patients with this condition still have intractable seizures, intellectual disability, behavioral problems, and physical comorbidities.
What is the rarest form of epilepsy?
Dravet Syndrome
- Dravet syndrome is a rare, drug-resistant epilepsy that begins in the first year of life in an otherwise healthy infant.
- Most cases are due to severe SCN1A gene mutations.
- Most children develop varying degrees of developmental disability.
What’s the worst type of epilepsy?
A grand mal seizure causes a loss of consciousness and violent muscle contractions. It’s the type of seizure most people picture when they think about seizures. A grand mal seizure also known as a generalized tonic-clonic seizure is caused by abnormal electrical activity throughout the brain.
What is Lennox-Gastaut syndrome and Dravet syndrome?
Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome (DS) are two of the various, rare epileptic disorders classified as epileptic encephalopathies. LGS is estimated to occur in 0.1 to 0.28 people per 100,000 and is believed to account for one to four percent of all cases of childhood epilepsy.
What is the average life expectancy of someone with epilepsy?
Between 1970 and 1980, patients diagnosed with symptomatic epilepsy had a substantially greater reduction in life expectancy (7.4 years in women and 7.2 years in men) than people diagnosed with idiopathic epilepsy (5.5 years in women and 5.2 years in men) and people diagnosed with cryptogenic epilepsy (1.8 years
When was Lennox-Gastaut syndrome discovered?
LGS was described in 1966 by the Marseille School in France, where Gastaut et al. (1966) generously proposed the term Lennox syndrome to denote a childhood-onset epilepsy characterized by frequent tonic and absence seizures.
Does seizure cause brain damage?
To summarize, prolonged seizures can result in brain damage, while recurring seizures can also have adverse effects on brain functioning. In turn, traumatic brain injuries can also lead to various types of seizures, which may cause further damage.
Is Fintepla approved for LGS?
The company’s first rare disease therapy, FINTEPLA® (fenfluramine) oral solution, has been approved by the U.S. FDA and the European Medicines Agency and is in development in Japan for the treatment of seizures associated with Dravet syndrome and LGS, both rare, severe lifelong epilepsies.
What is West syndrome?
West syndrome is a constellation of symptoms characterized by epileptic/infantile spasms, abnormal brain wave patterns called hypsarrhythmia and intellectual disability.
How long does someone with Dravet syndrome live?
Dravet syndrome is a rare, severe, and lifelong form of epilepsy (seizure disorder). Most people affected by this condition have a good life expectancy. The disease typically starts in the first year of life, and around 80-85% of the children survive into adulthood.
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