Complex networks (including most biological networks) are known as scale-free networks and are characterized by a power-law degree distribution.These high-degree nodes are called hubs. In protein-protein interaction (PPI) networks hubs represent proteins with a large number of interactions, called hub proteins.
What is a hub protein?
A node with more than ten interactions (in reality these can number in the hundreds) with other nodes is considered a hub protein. Linkages of a particular node can be mutually exclusive (i.e. cannot exist at the same time) if their partners use the same interaction interface in that node protein.
What is the importance of hubs?
The purpose of a hub is to form a single network segment on which all devices can communicate directly with each other. Until the early 2000s, Ethernet hubs were widely used for home networking due to their simplicity and low cost. While broadband routers have replaced them in homes, hubs still serve a useful purpose.
Why are hub genes important?
Gene ontology function annotation indicates that hub genes are significantly represented in some biological processes such as eye development, G-protein coupled receptor complex, positive regulation of transcription, negative regulation of canonical Wnt signaling pathway, cytokine receptor activity, and activating
Why do hubs tend to be essential in protein networks?
Under this scenario, a hub is more likely to be essential than a non-hub simply because the hub has more interactions and thus a higher chance to engage in an essential interaction. Hence, the centrality-lethality rule is explained without the involvement of network architecture.
Whats is a hub?
Hubs. A hub is a physical layer networking device which is used to connect multiple devices in a network. They are generally used to connect computers in a LAN. A hub has many ports in it. A computer which intends to be connected to the network is plugged in to one of these ports.
What is hub and its types?
The three types are active, passive and intelligent. Active hubs amplify the incoming electric signal, whereas passive hubs do not amplify the electric signal. Intelligent hubs are kind of active hubs.
What is switch and hub?
Hub and Switch are both network connecting devices. Hub works at physical layer and is responsible to transmit the signal to port to respond where the signal was received whereas Switch enable connection setting and terminating based on need.Hub works in Physical Layer. Switch works in Data Link Layer.
What are hub genes Wgcna?
Highly connected intramodular hub genes tend to have high module membership values to the respective module. Hub gene. This loosely defined term is used as an abbreviation of highly connected gene. By definition, genes inside coexpression modules tend to have high connectivity.
Why do proteins interact?
Proteinprotein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect.
What is Wgcna RNA seq?
WGCNA uses a series of correlations to identify sets of genes that are expressed together in your data set. This is a fairly intuitive approach to gene network analysis which can aid in interpretation of microarray & RNA-seq data.
What is hub with example?
The definition of a hub is the center of something. An example of a hub is the center of a wheel. An example of a hub is an intersection of roads with many popular restaurants.The center part of a wheel, fan, or propeller.
What is hub Wikipedia?
A hub is the central part of a wheel that connects the axle to the wheel itself.
What is repeater and hub?
Repeater has two ports: one for incoming signal and another one for boosted outgoing signal. Hub is able to join more than two signals. It takes the signal, boosts it, and transmits to all its ports. Typically hub can connect from 8 to 24 connections together.
What are the 3 kinds of hubs?
There are three types of network hubs: passive, active, and intelligent.
What are the 2 types of hubs?
There are two primary types of hubs in the computing world: 1) network hubs and 2) USB hubs.
- Network hub. A network hub is a device that allows multiple computers to communicate with each other over a network.
- USB hub. A USB hub is a device that allows multiple peripherals to connect through a single USB port.
What is hub class8?
Hub: A hub is a device that is used to connect computers in a network (Fig. 1.23). In a hub, when one computer sends data on the network, the hub simply forwards the packets to all the other computers connected to it (Fig. 1.26).
Why hub is used in physical layer?
Why hub is a physical layer device? Hub is used in a physical layer because it is not an intelligent device, it does not maintain any kind of table like a switch. It works like a cable (or connector), it’s just simple blindly forward data to all the connected devices like a cable.
What is hub and router?
A hub and a router are both electronic devices used in computer systems networking. A router is a more sophisticated device with both hardware and software that is used to connect multiple area networks (LANs and WANs), or two or more logical subnets. See also Hub vs. Switch.
Are hubs still used today?
Hubs are now largely obsolete, having been replaced by network switches except in very old installations or specialized applications. As of 2011, connecting network segments by repeaters or hubs is deprecated by IEEE 802.3.
What is a WGCNA module?
Weighted gene co-expression network analysis (WGCNA) is a bioinformatics application for exploring the relationships between different gene sets (modules), or between gene sets and clinical features (Langfelder and Horvath, 2008).
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