Dosage formulations for acute bipolar mania
| DEPAKOTE Delayed-Release Tablets | DEPAKOTE ER Tablets | |
|---|---|---|
| MAXIMUM RECOMMENDED DOSE | 60 mg/kg/day | |
| THERAPEUTIC BLOOD RANGE | Clinical response was dosed at trough plasma concentrations between 50-125 μg/mL | 85 to 125 μg/mL |
Is 1000mg of Depakote a lot?
The recommended starting dose of Depakote for the prevention of migraine is 250 mg twice daily. The dose may be increased until migraine control is achieved. The maximum recommended dose is 1000 mg/day as needed.
Is 2000 mg of Depakote a lot?
The mean daily dose usually ranges between 1000 – 2000 mg valproate. Patients receiving daily doses higher than 45 mg/kg/day body weight should be carefully monitored. Continuation of treatment of manic episodes in bipolar disorder should be adapted individually using the lowest effective dose.
Is 1500 mg of Depakote too much?
Depakote tablets are administered orally. The recommended starting dose is 250 mg twice daily. Some patients may benefit from doses up to 1,000 mg/day. In the clinical trials, there was no evidence that higher doses led to greater efficacy.
How much Depakote can you take in a day?
Adults—At first, 750 milligrams (mg) once a day, usually divided in smaller doses. Your doctor may increase your dose as needed. However, the dose is usually not more than 60 mg per kilogram (kg) of body weight per day. Children—Use and dose must be determined by your doctor.
How does Depakote work for bipolar?
Anticonvulsants are sometimes taken to treat the manic episodes associated with bipolar disorder. Depakote is sometimes prescribed when patients experience rapid cycling of mood episodes and works by calming the hyperactivity of the brain during mania.
How many mg of Depakote does it take to overdose?
400 — 1000 mg/kg: severe toxicity, i.e. Coma. >1g/kg: potentially life threatening, i.e. profound coma, multi-organ toxicity including hypotension, metabolic (lactic) acidosis, cerebral oedema, biochemical abnormalities, bone marrow suppression.
How many hours apart should Depakote be given?
Since Depakote ER is generally taken once every 24 hours, they should allow an interval of about 12 hours before taking the second dose, and then resume a 24-hour schedule the next day. Patients who often forget doses may benefit from using a special pillbox or watch with an alarm.
Can Depakote make you manic?
The symptoms vary widely in their pattern, severity, and frequency. Some people may alternate between extreme episodes of mania and depression. Antiepileptic drugs, including Depakote may cause suicidal thoughts or actions in a small number of people, about 1 in 500.
What is Depakote 500mg used for?
Divalproex sodium is used to treat certain types of seizures (epilepsy). This medicine is an anticonvulsant that works in the brain tissue to stop seizures. Divalproex sodium is also used to treat the manic phase of bipolar disorder (manic-depressive illness) and helps prevent migraine headaches.
How do you feel on Depakote?
Common side effects
- Nausea or vomiting.
- Headache.
- Drowsiness or dizziness.
- Tremor.
- Muscle weakness.
- Insomnia.
- Hair loss.
- Weight gain.
How long does it take Depakote to reach therapeutic levels?
Peak levels of valproate in the blood are reached in 7 to 14 hours. At equal doses, the bioavailability of Depakote ER is about 89% that of regular Depakote. To achieve equivalent bioavailability, the once-daily dose of Depakote ER needs to be 8% to 20% higher than the total multiple daily doses of Depakote.
How long does it take for Depakote to work for bipolar?
How long does it take for divalproex (Depakote) to start working? While it only takes a few hours for your body to fully absorb divalproex (Depakote), it can take a few weeks before you start to notice a difference in your symptoms. If you’re not seeing any improvement after 6 to 8 weeks, let your provider know.
How often should Depakote levels be monitored?
Monitor Depakote levels, liver function tests, and CBC with diff every 3-6 months.
Should Depakote be taken in the morning or at night?
A: You should take Depakote at a time of day when you can best remember to take it consistently—for instance, in the morning with breakfast or in the evening before you go to bed. Please see Full Prescribing Information with Medication Guide for the complete list of side effects.
Is Depakote good for bipolar 2?
Bipolar disorder is often treated with medications referred to as mood stabilizers, such as lithium or Depakote (valproate) and Tegretol (carbamazepine). These medications can be very effective in treating hypomania or mania and preventing the recurrence of bipolar episodes.
Which is better for bipolar lithium or Depakote?
Divalproex was as effective in rapid-cycling manic patients as in other patients. Conclusions: Both divalproex and lithium were significantly more effective than placebo in reducing the symptoms of acute mania. The efficacy of divalproex appears to be independent of prior responsiveness to lithium.
Is Depakote used for bipolar 1 or 2?
Depakote Delayed-Release Tablets and Depakote ER are used to treat manic episodes associated with bipolar disorder.
What level of Depakote is toxic?
Its action is similar to that of other common anticonvulsants, such as phenytoin and carbamazepine. The therapeutic range for valproic acid is 50-100 mcg/mL. The toxic level is >100 mcg/mL.
What happens if you take too many divalproex?
If you stop taking it suddenly: If you’re taking this drug to treat seizures, stopping it suddenly can cause a seizure that won’t stop (status epilepticus). If you take too much: Taking too much of this drug can cause dangerous effects, such as: extreme fatigue.
Can Depakote ER be taken twice a day?
Depakote Delayed-Release Tablets are “delayed-release,” which means they have a special coating that prevents the drug from dissolving too early in the digestive tract. Available in three strengths, Depakote Delayed-Release Tablets must be taken twice a day, as prescribed by your doctor.
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