Discounts for Prior Students at Certara University
| Previously Completed Course | Discounted Certification Exam Price |
|---|---|
| Fundamentals of Pharmacokinetics (103-OD) | $199 |
| NCA Data Analysis (105-OD) | $199 |
| Introduction to Phoenix WinNonlin (100-OD or 100-CL) | $50 |
| (100-OD or 100-CL) and (103-OD or 105-OD) | $50 |
What is phoenix WinNonlin?
Phoenix WinNonlin is a non-compartmental analysis (NCA), pharmacokinetic/pharmacodynamic (PK/PD), and toxicokinetic (TK) modeling tool, with integrated tools for data processing, post-analysis processing including statistical tests and bioequivalence analysis, table creation, and graphics.
What is WinNonlin used for?
WinNonlin is a pharmacokinetic software package that has grown and evolved over the past 20 years. The most familiar versions of WinNonlin (v3 – v5) were stand-alone Windows-based software packages used to perform non-compartmental analysis and single subject non-linear model fitting.
How much does WinNonlin cost?
Discounts for Prior Students at Certara University
| Previously Completed Course | Discounted Certification Exam Price |
|---|---|
| NCA Data Analysis (105-OD) | $199 |
| Introduction to Phoenix WinNonlin (100-OD or 100-CL) | $50 |
| (100-OD or 100-CL) and (103-OD or 105-OD) | $50 |
| Introduction to Phoenix NLME (101-OD or 101-CL) | $50 |
What does PK PD stand for?
pharmacokinetic/pharmacodynamic modeling
PK/PD modeling (pharmacokinetic/pharmacodynamic modeling) (alternatively abbreviated as PKPD or PK-PD modeling) is a technique that combines the two classical pharmacologic disciplines of pharmacokinetics and pharmacodynamics.
What is non compartmental analysis?
Non-compartmental analysis (NCA) is a simple and quick method for evaluating the exposure of a drug. It allows you to evaluate things like linearity and in vivo exposure. To illustrate this consider an antibody given in a subcutaneous injection.
What is half life of a drug?
The half-life of a drug is the time it takes for the amount of a drug’s active substance in your body to reduce by half. This depends on how the body processes and gets rid of the drug. It can vary from a few hours to a few days, or sometimes weeks.
What the body does to the drug is called?
Pharmacokinetics, sometimes described as what the body does to a drug, refers to the movement of drug into, through, and out of the body—the time course of its absorption.
What does PBPK stand for?
Physiological based pharmacokinetic modeling and simulation
Physiological based pharmacokinetic modeling and simulation (PBPK) is a computer modeling approach that incorporates blood flow and tissue composition of organs to define the pharmacokinetics (PK) of drugs. The concept of PBPK was first described by Teorell in 1937.
What is NCA in clinical trial?
National Coverage Analysis (NCA)
When an NCD is under consideration, either a new review or a reconsideration, there are numerous documents that support the process. These documents are considered the NCA.
What is NCA drug?
Noncompartmental analysis (NCA) provides the most elementary pharmacokinetic information for a drug (i.e., peak concentration and elimination half-life). NCAs are essential for characterizing new drug products and can help guide development at each stage.
How does PK calculate MRT?
The MRT is calculated by summing the total time in the body and dividing by the number of molecules, which is turns out to be 85.6 minutes.
What is bioavailability of a drug?
Bioavailability refers to the extent a substance or drug becomes completely available to its intended biological destination(s).
Is half-life free?
Half-Life: Alyx will launch in March 2020 for PC-based VR headsets, but right now, Valve is giving gamers the opportunity to catch up on (almost) everything Half-Life-related at no expense. For the next two months, each of the Half-Life games will be free to play on Steam.
What drug has the shortest half-life?
This class of drugs has evolved from a drug such as amlodipine, with a long duration of action related to prolonged plasma half-life, to lercanidipine, which has the shortest plasma half-life relative to its intrinsically long duration of action.
What is F pharmacokinetics?
F = fraction absorbed (bioavailability) K0 = infusion rate. T = duration of infusion.
What is good solubility for a drug?
A drug is considered highly soluble when the highest dose strength is soluble in 250 mL or less of aqueous media over the pH range of 1 to 7.5.
What are the 4 categories of drug actions?
There are four types of ligand that act by binding to a cell surface receptor, agonists, antagonists, partial agonists, and inverse agonists (Figure 1). Ligand s that bind to a receptor and produce an appropriate response are called agonists.
Is PK SIM free?
PK-Sim® and MoBi® for PBPK and Quantitative Systems Pharmacology. Reliable, powerful and easy-to-use modeling & simulation tools for pharmaceutical and other life-sciences applications. Qualified and accepted by the scientific community including academia, regulatory agencies and industry. Available free to everyone.
What is linear PK?
Linear Pharmacokinetics ,the characteristic of drugs that indicates the instantaneous rate of change in drug concentration depends only on the current concentration. The half-life will remain constant, irrespective of how high the concentration.
What is KP pharmacokinetics?
Kp values are defined as the ratio of total concentration of compound in the tissue to total concentration of compound in the plasma at steady state.
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