Graphene nanomaterials are outstanding carrier materials for drug delivery applications. The specific structure-associated properties enable high loading efficiency, functionalization capacity for targeting, imaging, sensing, stimuli responsive release, etc.
What is graphene used for in medicine?
Graphene oxide (GO), an oxidized derivative of graphene, is currently used in biotechnology and medicine for cancer treatment, drug delivery, and cellular imaging. Also, GO is characterized by various physicochemical properties, including nanoscale size, high surface area, and electrical charge.
Why is graphene oxide used in medicine?
Graphene and graphene oxide have been widely investigated for biomedical applications due to their exceptional qualities: twodimensional planar structure, wide surface area, chemical and mechanical constancy, sublime conductivity and excellent biocompatibility.
Which drugs use graphene oxide?
Table 1
| GO composite | Drug/gene | References |
|---|---|---|
| CPMAA2-GON-PEG | DOX | 103 |
| PAA-GO | BCNU | 104 |
| NGO-SS-PE | DOX | 105 |
| Graphene/Fe3O4 | DOX | 106–108 |
Which nanoparticles are used in drug delivery?
Nanoparticles used in drug delivery system
- Chitosan. Chitosan exhibits muco-adhesive properties and can be used to act in the tight epithelial junctions.
- Alginate.
- Xanthan gum.
- Cellulose.
- Liposomes.
- Polymeric micelles.
- Dendrimers.
- Inorganic nanoparticles.
What are the side effects of graphene oxide?
Concentration. Numerous results have shown that graphene materials cause dose-dependent toxicity in animals and cells, such as liver and kidney injury, lung granuloma formation, decreased cell viability and cell apoptosis [130–134].
Why is graphene useful to humans?
3) Use graphene, or chemically modified graphene material, that can be easily cleared from or biodegraded in the body, to prevent damage from chronic accumulation into tissues.
Is graphene hydroxide used in medicine?
The biomedical applications of graphene and its composite include its use in gene and small molecular drug delivery. It is further used for biofunctionalization of protein, in anticancer therapy, as an antimicrobial agent for bone and teeth implantation.
How is graphene used in biomedicine?
One of the earliest biomedical applications of graphene was for improved drug delivery.Graphene oxide contains COOH and OH groups which will readily allow for the attachment to various biomolecules. Studies have explored the use of graphene oxide for the delivery of cancer treatments and anti-inflammatory drugs.
Graphene materials show excellent inhibitory antiviral effects against enveloped and non-enveloped viruses, including RNA and DNA viruses. These performances which are attributed to the physicochemical properties exhibited on the surfaces of these materials, can be used to control the COVID-19 pandemic.
How do nanoparticles work in drug delivery?
Due to their small size and large surface area, drug nanoparticles show increase solubility and thus enhanced bioavailability, additional ability to cross the blood brain barrier (BBB), enter the pulmonary system and be absorbed through the tight junctions of endothelial cells of the skin (Kohane, 2007).
What is drug delivery in nanotechnology?
Nanotechnology drug delivery applications occur through the use of designed nanomaterials as well as forming delivery systems from nanoscale molecules such as liposomes. Applying nanotechnology to drug delivery should achieve the following benefits: Improve the ability to deliver drugs that are poorly water soluble.
What are the types of drug delivery systems?
Figure 1: Different routes of drug delivery.
- Buccal drug delivery.
- Nasal drug delivery.
- Ocular drug delivery.
- Oral drug delivery.
- Pulmonary drug delivery.
- Sublingual drug delivery.
- Transdermal drug delivery.
- Vaginal/anal drug delivery.
How do you detect graphene oxide?
Just one drop of blood for a diagnosis
A single drop of blood or saliva is all it takes to perform an accurate analysis. Just a few minutes after the drop is applied to the sensor’s surface, electrical signals convey the test result to the family doctor’s office.
What does graphene do to the blood?
Even though graphene oxide is made with the same atoms as our organs, tissues and cells, its bi-dimensional nature causes unique interactions with blood proteins and biological membranes and can lead to severe effects like thrombogenicity and immune cell activation.
How long does it take for graphene oxide to leave the body?
In fact, over 75% of graphene oxide (or GO) sheets injected into mice were eliminated from the body through the kidneys in the urine within 24 hours.
What is graphene used for today?
Graphene has a lot of promise for additional applications: anti-corrosion coatings and paints, efficient and precise sensors, faster and efficient electronics, flexible displays, efficient solar panels, faster DNA sequencing, drug delivery, and more.
What are the disadvantages of graphene?
Some of the major disadvantages of graphene include but are not limited to;
- Being a great conductor of electricity, although it doesn’t have a band gap (can’t be switched off).
- The main disadvantage of graphene as a catalyst is its susceptibility to oxidative environments.
How much does graphene cost?
However, as graphene currently ranges at anywhere between $67,000 and $200,000 a ton, there is a lot of potential to significantly reduce the cost of graphene products—perhaps, by even up to an order of magnitude.
Is graphene toxic?
Rationales provided for this are that graphene is not toxic, that exposure is low, that small amounts are expected to be produced and used, that graphene can be made safe, that graphene is similar to harmless materials (e.g., being “just carbon”), and that graphene is different from hazardous materials such as carbon
What is meant by graphene oxide?
Graphene oxide (GO) is a unique material that can be viewed as a single monomolecular layer of graphite with various oxygen-containing functionalities such as epoxide, carbonyl, carboxyl, and hydroxyl groups.
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