At the end of the study, 68.5% of study participants reported erectile dysfunction. Frequency of erectile dysfunction was significantly higher in patients receiving sodium valproate or carbamazepine compared with control group (Table 4).
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Can valproic acid cause erectile dysfunction?
VPA-dependent obesity and hyperinsulinemia can further contribute to an increase in sexual dysfunctions. Conclusions: VPA interferes with the endocrine system at multiples levels causing several reproductive and sexual dysfunctions in women and men with epilepsy, especially when administered in pubertal age.
Does sodium valproate affect testosterone?
Patients on sodium valproate therapy showed minor changes in serum sex hormone level. The total testosterone level fell significantly (p<0.05) at the end of 1 year, however LH, FSH and serum prolactin levels remained unaltered.
What are the main side effects of sodium valproate?
Common side effects
- stomach pain, feeling or being sick.
- diarrhoea.
- dry or sore mouth, or swollen gums.
- shakes (tremors) in a part of your body, or unusual eye movements.
- feeling tired or sleepy.
- headache.
- weight gain.
- thinning hair, or changes to the colour or texture of your hair.
Can epilepsy medication cause erectile dysfunction?
Expert opinion: SD related to AEDs is common. Symptoms include erectile dysfunction (ED), hyposexuality, hypersexuality and ejaculatory dysfunction. Traditional AEDs such as valproate and enzyme-inducing AEDs (EIAEDs) may produce high incidences of decreased libido.
Does sodium valproate affect male fertility?
There is no evidence to suggest that there is any associated risk for babies born to men who are taking sodium valproate. However, some research suggests sodium valproate may affect the amount of sperm a man produces and the motility of the sperm.
Which drugs can cause erectile dysfunction?
Drugs that may cause erection problems
- Amitriptyline (Elavil)
- Amoxapine (Asendin)
- Buspirone (Buspar)
- Chlordiazepoxide (Librium)
- Chlorpromazine (Thorazine)
- Clomipramine (Anafranil)
- Clorazepate (Tranxene)
- Desipramine (Norpramin)
Does divalproex sodium cause erectile dysfunction?
Sexual side effects
Depakote interferes with the endocrine system and, according to one study, can cause reproductive and sexual dysfunction in both men and women. The most common sexual side effects were erectile dysfunction and decreased libido.
Can phenytoin cause erectile dysfunction?
Most anticonvulsant drugs prescribed to treat epilepsy do not cause erectile dysfunction (ED). The one exception is phenytoin (Dilantin), which can cause problems getting and maintaining an erection in some men. If think your medication is causing ED, don’t stop taking it without talking to your doctor first.
Can Tegretol cause erectile dysfunction?
Carbamazepine has also been shown to induce the hepatic synthesis of sex hormone-binding globulin, thus reducing free serum testosterone levels and possibly causing erectile dysfunction (ED) in some men; these effects have not been observed with oxcarbazepine.
Can I take Viagra if I have epilepsy?
Sildenafil has been recognized as adequate in the treatment of erectile dysfunctions in men with epilepsy.
How long does it take to get sodium valproate out of your system?
It is highly plasma protein bound and has a half-life of 8–20 hours in most patients, but this may occasionally be much longer, for example in renal impairment or overdose. The relationship between dose, plasma concentration and therapeutic effect is not well understood.
What is Epilim 100mg used for?
Epilim is a medicine used for the treatment of epilepsy in adults and children. Epilepsy is a condition where you have repeated seizures (fits). There are many different types of seizures, ranging from mild to severe. Epilim belongs to a group of medicines called anticonvulsants.
What is epilim 200 used for?
Epilim contains sodium valproate. It belongs to a group of medicines called anti-convulsants or anti-epileptic agents. It works by helping to calm the brain down. Epilim is used to treat epilepsy (fits) in adults and children.
Does epilepsy medication affect sperm?
You may be taking an epilepsy medicine that can reduce the amount of sperm you produce or affect the quality of it. Carbamazepine, phenytoin and sodium valproate may all have this effect. There’s a small amount of evidence that levetiracetam may also affect the number and quality of sperm you produce.
Does valproate affect sperm?
Valproate therapy can result in reduced sperm count, motility and abnormal morphology. Valproate’s adverse effects on male fertility are reversible in some patients. Abnormalities may be dependent on the dose and the duration of Valproate treatment.
Can oxcarbazepine cause erectile dysfunction?
Similar to our study, previous studies demonstrated erectile dysfunction, hyposexuality and ejaculatory dysfunction as side effects of AEDs [6]. Dose-related anorgasmia has been also reported in patients receiving oxcarbazepine [15]. Moreover, another AED, topiramate can provoke erectile dysfunction [16].
Can I marry a man with epilepsy?
There is no reason why an epileptic person cannot get married and have children and lead a normal life. However, correct diagnosis is required as there are several kinds of epileptic seizures. Proper medication and precautions need to be taken though.
What causes sudden erectile dysfunction?
Causes of Sudden ED
Excessive alcohol intake. Medications such as sedatives, antidepressants, appetite suppressants, or blood pressure medication. Smoking or drug use.
How do you fix erectile dysfunction?
Here are some steps that might help:
- If you smoke, quit. If you have trouble quitting, get help.
- Lose excess pounds. Being overweight can cause — or worsen — erectile dysfunction.
- Include physical activity in your daily routine.
- Get treatment for alcohol or drug problems.
- Work through relationship issues.
What is the fastest way to cure ED?
What Are Some Natural ED Remedies That You Can Implement?
- Exercise Regularly. A healthy way of life prevents a lot of medical problems, including erectile dysfunction.
- Consume Healthy Food.
- Attend Therapy.
- Avoid Smoking or Over-Consuming Alcohol.
- Get Enough Sleep.
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